DIM
Diindolylmethane, with Curcumin, Green Tea and Wasabia
DESCRIPTION
DIM, provided by Douglas Laboratories, is a synergistic combination of plant based ingredients including diindolylmethane, curcumin, green tea, and wasabia designed to support healthy hormone balance and immune health.
FUNCTIONS
During the body’s natural detoxification processes, potentially detrimental molecules such as hormone metabolites, alcohol, drugs and air pollutants are removed from the blood stream via the liver. Healthy hormone detoxification is a crucial part of the normal functioning of the immune system.
Diindolylmethane (DIM) is one molecule known for the supportive role it plays in stimulating natural detoxification enzymes and supporting normal hormone metabolism. As a natural component derived from indole-3-carbinole and cruciferous vegetables, DIM has shown in studies to support the 2-hydroxylation instead of 16-hydroxylation of certain estrogen metabolites. This favors the production of 2-hydroxysterone over the more deleterious 16-hydroxyestrone. Other studies indicate that DIM may play important roles in inducing apoptosis and supporting the body’s normal angiogenic balance.
Scientists have identified numerous phytochemicals including polyphenols, methylxanthines, flavonoids, and triterpenoid saponins in green tea. The polyphenols contained in tea, specifically the catechins, appear to provide the primary health promoting benefits associated with green tea consumption. Catechin, epicatechin, epigallocatechin (EGC), and most notably EGCG, epigallocatechin gallate act as antioxidants and support immune function, cardiovascular health and hormone detoxification. Additionally, in vitro, these nutrients have been shown to support healthy cell growth and division.
Studies have shown that curcumin, a naturally occurring biologically active group of compounds from Curcuma
longa (Turmeric), can function as efficient antioxidants and can help regulate the body’s normal response to inflammatory processes. Curcumin can also play an important role in maintaining healthy angiogenic balance and help to support the body’s detoxification processes.
Wasabia, a member of the cruciferous vegetable family, contains long chain isothiocyanates (ITCs). These ITCs are believed to be 10-25 times more potent in the detoxification process than most ITCs found in cruciferous vegetables. These long chain ITCs are unique to wasabia and are not commonly found in other cruciferous vegetables. This formula also included Bioperine pepper extract for enhanced absorption.
INDICATIONS
DIM may be a useful dietary supplement for individuals wishing to support healthy hormone detoxification.
FORMULA (#99598)
2 vegetarian capsules contain:
Curcumin extract (root) ................................ 600.. mg
(standardized to 95% curcuminoids)
Green tea extract (leaf) ................................. 400.. mg
(standardized to 95% polyphenols and 45% EGCG)
DIM(diindolylmethane) ................................ 300 mg
Wasabia japonica (rhizome) ....................... 100.. mg
(containing at least 1,200 mcg of isothiocyantes as allyl ITC, 3-butenyl ITC, and 4-pentyl ITC)
Bioperine® (pepper extract) ............................ 10.. mg
SUGGESTED USE
Adults take 2 capsules daily or as directed by your healthcare professional.
SIDE EFFECTS
No adverse side effects reported.
STORAGE
Store in a cool, dry place, away from direct light. Keep out of reach of children.
REFERENCES
Bonnesen C, Eggleston IM, Hayes JD. Dietary indoles and isothiocyanates that are generated from cruciferous vegetables can both stimulate apoptosis and confer protection against DNA damage in human colon cell lines. Cancer Res 2001 Aug 15;61(16):6120-30.
Chen DZ, Qi M, Auborn KJ, Carter TH. Indole-3-carbinol and diindolylmethane induce apoptosis of human cervical cancer cells and in murine HPV16-transgenic preneoplastic cervical epithelium. J Nutr 2001 Dec;131(12):3294-302.
Fitch MD, Bradlow HL, Bjeldanes LF. Pilot study: effect of 3,3'-diindolylmethane supplements on urinary hormone metabolites in postmenopausal women with a history of early-stage breast cancer. Nutr Cancer. 2004;50(2):161-7.
Fujiki H et al. Cancer inhibition by green tea. Mutat Res 1998;402(1-2):307-10.